QB3 High Throughput Screening Facility

The High-Throughput Screening Facility (HTSF), located in the Li Ka Shing Center for Biomedical and Health Sciences, provides access to cell culturing space, automated liquid handling, automated plate reader and high-throughput, high-content microscopy instrumentation for screening experiments, along with tools for analysis and data visualization. Emphasis is on whole genome and sub-library siRNA screening from various sources but other high-throughput fluidics projects are welcome.

Berkeley Bay Area Cryo-EM Facility (BACEM)

The Berkeley BACEM Facility, housed in Stanley Hall, is led by Professor Eva Nogales and is expected to begin operation in fall 2016. This cryo-EM resource is mostly dedicated to single particle studies that aim for high-resolution structures and the description of complex biochemical or conformational co-existing states. The facility is supported by the member institutions of the BACEM consortium, and acquisition of the instrumentation was funded by HHMI.

Biological Imaging Facility

"A state-of-the-art light microscopy facility specializing in live and fixed cell imaging. Specializes in Widefield, Spinning-Disk Confocal, Laser Scanning Confocal, Deconvolution and Super-Resolution fluorescence microscopy. Also advanced software for image analysis and presentation (Imaris, HuygensPro), as well as microtechnique (both paraffin/plastic and cryotomy) equipment and training.

Brain Imaging Center

The Brain Imaging Center's MRI facility houses an actively-shielded 3 Tesla Siemens TIM/Trio scanner. The 32-channel console is equipped with 12- and 32-channel receive-only head coils as well as a custom-made birdcage coil. The scanner is capable of high-performance EPI for fMRI, diffusion imaging, perfusion imaging, high resolution anatomical scanning and a wide range of standard clinical sequences.

Electron Microscope Laboratory

Provides EM services to the Berkeley campus and the academic community at large. The EML houses both TEMs and SEMs and provides three types of service: (1) education and training, (2) equipment for trained users, and (3) full service microscopy for pilot studies. The EML specializes in cryopreservation via HPF/FS. All services are available to anyone with an interest in electron microscopy: graduate and undergraduate students, post-doctoral researchers, faculty, staff, and non-UC users.

CRL Molecular Imaging Center

A state-of-the-art light microscopy facility specializing in imaging live cell and live small model organisms (zebrafish, drosophila, c. elegans, etc.), laser-scanning and spinning disk confocal microscopy, multi-photon microscopy, fluorescence lifetime imaging (FLIM), super resolution (AiryScan and Fast Airyscan), light-sheet microscopy (SPIM), holographic patterned illumination for optogenetic studies, and slide scanning with histological stains and fluorescence.