The Jagust Lab is a joint research program involving the UC Berkeley Helen Wills Neuroscience Institute, UC Berkeley School of Public Health, and the Lawrence Berkeley National Laboratory (LBNL). The primary focus of the laboratory is the study of brain aging and dementia. We use multimodal imaging techniques - including positron emission tomography, magnetic resonance imaging, and functional magnetic resonance - to study the brain. Research participants include normal older and younger individuals and patients with a variety of different dementias. Many students and postdoctoral fellows at all levels participate in research projects. Key projects include imaging the deposition of beta-amyloid and tau in the aging brain, and examining the effects of these aggregated proteins on brain structure and function.
In the News
New research led by scientists at UC Berkeley shows for the first time that PET scans can track the progressive stages of Alzheimer’s disease in cognitively normal adults, a key advance in the early diagnosis and staging of the neurodegenerative disorder.
Sleep may be a missing piece of the Alzheimer’s puzzle. The toxic protein that is the hallmark of Alzheimer’s disease blocks the deepest stages of sleep, resulting in memory decline, according to new research.
If early intervention is key, then so is the ability to detect even the slightest sign of neurological damage. The William Jagust Lab is using statistical and computational approaches to refine PET scan sensitivity to identify a possible Alzheimer precursor.
UC Berkeley researchers have found that the human brain is capable of a neural workaround that compensates for the buildup of beta-amyloid, a destructive protein associated with Alzheimer’s disease. The findings could help explain how some older adults with beta-amyloid deposits in their brain retain normal cognitive function while others develop dementia.
William J. Jagust, an authority on brain aging and dementia, has been awarded the 2013 Potamkin Prize for Research in Pick’s, Alzheimer’s and Related Diseases by the American Academy of Neurology and the American Brain Foundation.
For the past five years, volunteers from the City of Berkeley and surrounding areas have come to Berkeley Lab to participate in an ongoing study that’s changing what scientists know about Alzheimer’s disease. The goal of the Berkeley Aging Cohort Study is to reveal how our brains change as we age.
People who have made mental engagement a lifelong habit have lower levels of a key protein linked to Alzheimer's disease, according to a new study led by UC Berkeley neuroscientists. The findings could provide support for cognitive therapies to prevent the onset of a debilitating disease.