Michael Rape

Michael Rape

Title
Dr. K. Peter Hirth Chair of Cancer Biology; Professor of Cell and Developmental Biology; Investigator, HHMI
Department
Dept of Molecular & Cell Biology
Phone
(510) 642-0468
Fax
(510) 642-6420
Research Expertise and Interest
cancer, protein degradation, siRNA, Berkeley Screening Center
Research Description
We are implementing a combination of biochemistry, cell biology, and high-throughput genetic screening to identify enzymes required for protein degradation. We are particularly interested in studying those enzymes that control cell division and differentiation, two processes often misregulated in cancer.

In the News

May 9, 2013

Howard Hughes Medical Institute names three new campus investigators

Nicole King, Russell Vance and Michael Rape took different routes to UC Berkeley’s Department of Molecular and Cell Biology, but they’ve ended up with one of the mostly highly sought positions at any American university: a fully subsidized appointment, with added research funds, as a Howard Hughes Medical Institute (HHMI) investigator.

April 8, 2013

The Cell’s “Everywhere” Molecule

Michael Rape studies ubiqutins that form chains, “like pearls on a string,” he says. In 2008, his lab discovered a new member of this chain configuration and determined how an enzyme called Ube2S is able to assemble it inside cells. Without the Ube2S enzyme and the ubiquitin chain, he found, cells cannot divide. But with too much Ube2S – and too many ubiquitin chains – cell division runs out of control.

February 6, 2013

Bakar Fellow Dr. Michael Rape awarded the Vilcek Prize for Creative Promise in Biomedical Science

Dr. Michael Rape, Bakar Fellow and Associate Professor of Cell and Development and Biology at UC Berkeley, was awarded the Vilcek Prize for Creative Promise in Biomedical Science. He is a leading biochemical researcher helping to unravel the mysteries of the ubiquitin system, which tags damaged or bad proteins for destruction, and others for elimination to enable certain processes to occur, and therefore vital to the health of all life-forms.

July 19, 2012

Bakar Fellows advance commercially promising research

In its first year, the initiative will give research innovations by six early-career UC Berkeley faculty members — including technologies to move prosthetic limbs with the power of thought and to control Argentine ants using their own pheromones — a significant boost from the lab to the market.

In the News

May 9, 2013

Howard Hughes Medical Institute names three new campus investigators

Nicole King, Russell Vance and Michael Rape took different routes to UC Berkeley’s Department of Molecular and Cell Biology, but they’ve ended up with one of the mostly highly sought positions at any American university: a fully subsidized appointment, with added research funds, as a Howard Hughes Medical Institute (HHMI) investigator.

April 8, 2013

The Cell’s “Everywhere” Molecule

Michael Rape studies ubiqutins that form chains, “like pearls on a string,” he says. In 2008, his lab discovered a new member of this chain configuration and determined how an enzyme called Ube2S is able to assemble it inside cells. Without the Ube2S enzyme and the ubiquitin chain, he found, cells cannot divide. But with too much Ube2S – and too many ubiquitin chains – cell division runs out of control.

February 6, 2013

Bakar Fellow Dr. Michael Rape awarded the Vilcek Prize for Creative Promise in Biomedical Science

Dr. Michael Rape, Bakar Fellow and Associate Professor of Cell and Development and Biology at UC Berkeley, was awarded the Vilcek Prize for Creative Promise in Biomedical Science. He is a leading biochemical researcher helping to unravel the mysteries of the ubiquitin system, which tags damaged or bad proteins for destruction, and others for elimination to enable certain processes to occur, and therefore vital to the health of all life-forms.

July 19, 2012

Bakar Fellows advance commercially promising research

In its first year, the initiative will give research innovations by six early-career UC Berkeley faculty members — including technologies to move prosthetic limbs with the power of thought and to control Argentine ants using their own pheromones — a significant boost from the lab to the market.

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