Schekman Labs' research is devoted to a molecular description of the process of membrane assembly and vesicular traffic in eukaryotic cells. Basic principles that emerged from these studies in yeast are now being applied to studies of genetic diseases of protein transport.
A combination of genetic and cytologic evaluation of the secretion (sec) mutants has allowed a description of the secretory pathway in Saccharomyces cerevisiae. Protein transport in yeast appears to be mediated by the same organelles and proteins that operate in mammalian cells. Molecular cloning analysis of SECgenes revealed striking structural and functional homology with corresponding mammalian genes.
In the News
Newly minted Nobel Laureate Randy Schekman used his Nobel acceptance speech Dec. 10 in Stockholm to encourage more support for basic research, the “freedom of inquiry (that) nourished the careers of today’s Laureates.”
Randy W. Schekman, professor of molecular and cell biology at the University of California, Berkeley, has won the 2013 Nobel Prize in Physiology or Medicine for his role in revealing the machinery that regulates the transport and secretion of proteins in our cells. He shares the prize with James E. Rothman of Yale University and Thomas C. Südhof of Stanford University.
Cell biologist Randy Schekman, professor of molecular and cell biology and current editor of the Proceedings of the National Academy of Sciences, has been named the first editor of a new journal that the Howard Hughes Medical Institute, the Max Planck Society, and the Wellcome Trust aim to launch next year.