Lin He is a professor in molecular & cell biology and UC Berkeley with research interests in the functional importance of the non-coding genome. The number of protein-coding genes clearly fails to correlate with the developmental and pathological complexity in mammals. Her research group's overall research interest is to understand the unique biological functions and molecular regulation of various non-coding RNAs and transposable elements in development and disease. Her postdoctoral work has identified some of the first miRNAs in key oncogene and tumor suppressor pathways. Studies from her own lab have extended beyond mere identification of functionally important miRNAs; Her group aims to understand the distinct biological functions and molecular regulation conferred by miRNAs, long ncRNAs and retrotransposons in development and disease using an interdisciplinary approach combining mouse genetics, genomics, imaging studies, cell biology, and molecular biology. Their studies have provided important insights on the fundamental molecular mechanisms that govern the unique functional complexity of the non-coding genome.
Research Expertise and Interest
comparative genomics, developmental biology, cell biology, cancer biology
January 11, 2022
The Chan Zuckerberg Biohub announced today (Jan. 11) the second cohort of scientists to be named CZ Biohub Investigators, 21 of whom are UC Berkeley faculty members.
October 18, 2021
A new study led by researchers at University of California, Berkeley, and Washington University explored the function of one component of this junk DNA, transposons, which are selfish DNA sequences able to invade their host genome. The study shows that at least one family of transposons — ancient viruses that have invaded our genome by the millions — plays a critical role in viability in the mouse, and perhaps in all mammals.
May 14, 2018
Lin He’s lab uses CRISPR technology to study how different genetic elements in a mouse embryo’s cell nucleus – genes that encode proteins, functional RNAs, and repetitive sequences – interact to assure normal development or trigger cancer.