Lin He is an associate professor in molecular & cell biology and UC Berkeley with research interests in comparative genomic studies, the number of protein-coding genes clearly fails to correlate with the developmental and pathological complexity in mammals. Her research group's overall research interest is to understand the unique biological functions and molecular regulation of various non-coding RNAs in development and disease. Her postdoctoral work has identified some of the first miRNAs in key oncogene and tumor suppressor pathways. Studies from her own lab have extended beyond mere identification of functionally important miRNAs; we aim to understand the distinct biological functions and molecular regulation conferred by miRNAs and other non-coding elements in development and disease using an interdisciplinary approach combining mouse genetics, genomics, Xenopus genetics, cell biology, and molecular biology. Their studies have provided important insights on the fundamental molecular mechanisms that govern the unique functional complexity of the non-coding genome.
Research Expertise and Interest
comparative genomics, developmental biology, cell biology
May 14, 2018
Lin He’s lab uses CRISPR technology to study how different genetic elements in a mouse embryo’s cell nucleus – genes that encode proteins, functional RNAs, and repetitive sequences – interact to assure normal development or trigger cancer.