Jasper Rine is a Howard Hughes Medical Institute Professor and Professor of the Graduate School Division of Genetics, Genomics, Evolution, and Development. The research in his lab is focused on the yeast Saccharomyces cerevisiae in which they use genetic analysis to explore issues of gene regulation and cell biology. In addition, they are developing genomic-based approaches to the study of cells by parallel analysis of the expression of all genes simultaneously. Their goal is to create a new kind of genetic analysis in which the genome is used as the unit of function, rather than individual genes or proteins. The gene regulation work focuses on the coupling between certain origins of DNA replication and the establishment of domains with different transcriptional states. The cell biology work focuses on the regulation of the cholesterol biosynthetic pathway and the roles intermediates of this pathway play in the covalent modification of numerous proteins including the Ras oncoprotein and in the trafficking of prenylated proteins.
In the News
The National Academy of Inventors has elected three UC Berkeley faculty members to its ranks in honor of their innovation and creativity leading to patented inventions that have made a tangible impact on society.
Thanks to initial funding from the India-based Tata Consultancy Services, the Center for Computational Biology has launched a pioneering initiative to develop a software platform to analyze differences in people’s genomes and bring closer the day when one’s personal genome will be a starting point for health and medical advice.
The California Department of Public Health has instructed the University of California, Berkeley, not to proceed with a portion of its ground-breaking program to educate students about genetic testing and personalized medicine.