Research Expertise and Interest
stem cell niche engineering, tissue repair, stem cell aging and rejuvenation
A key direction of my laboratory is to understand age-imposed and pathological changes in molecular compositions of systemic and local environments of adult stem cells and to calibrate these to health - youth. In the past few years this direction has been ramified into synthetic biology, CRISPR technologies, bio-orhtogonal proteomics and development of innovative digital bio-sensors that we collaboratively applied to the fields of aging and diagnostics of genetic diseases. Success in this research will improve our understanding of the determinants of homeostatic health and will enable novel rational approaches to treat a number of degenerative, fibrotic, metabolic and inflammatory diseases, as a class.
a few links: https://engineering.berkeley.edu/news/2019/10/new-frontiers-in-gene-editing/, https://www.economist.com/science-and-technology/2019/09/12/uncovering-how-the-body-ages-is-leading-to-drugs-to-reverse-it, http://berkeleysciencereview.com/article/bloody-battle-aging/ https://www.economist.com/news/science-and-technology/21724967-might-be-true-people-too-blood-young-animals-can-revitalise-old. http://ww2.kqed.org/science/2014/07/21/new-uc-berkeley-study-shows-oxytocin-may-help-rejuvenate-aging-muscles/ https://www.sciencedaily.com/releases/2016/11/161122123102.htm, http://time.com/4579899/young-blood-transfusion-aging/