The overarching goal of our laboratory is to advance human health by re-engineer lipid fluxes in the context of obesity-related disorders to protect certain tissues, such as the liver, from detrimental effects of ectopic lipid deposition and to generate metabolically highly active tissues that can serve as a save destination for excess fatty acids. To this end, we are investigating molecular mechanisms governing lipid uptake, particularly for fatty acids and CoQ, hepatobiliary diseases, and adipocyte biology. Toward the later, we have been working on novel bioengineering based approaches to expand and activate brown adipose tissue. Further, to facilitate the assessment of altered nutrient fluxes, we have been developing and testing novel bioluminescent imaging approaches to quantitatively assess macro- and micronutrients in vivo and have been working as part of a multidisciplinary team toward modeling human metabolic function and disease using iPSC derived microphysiological devices, aka organs on a chip, for adipocytes, hepatocytes, and islets.
In the News
Scientists at UC Berkeley have developed a novel way to engineer the growth and expansion of energy-burning “good” fat, and then found that this fat helped reduce weight gain and lower blood glucose levels in mice.
Fad diets come and go, but might there be something to the ones that involve consuming grapefruit and grapefruit juice? New research found that mice fed a high-fat diet gained less weight when they drank grapefruit juice instead of water.
Two types of naturally produced substances — one of them a bear bile acid — reduce the uptake of fat by the liver, opening the door to the development of new treatments for fatty liver disease and type 2 diabetes, according to a new study by researchers at UC Berkeley.