The Energy & Biosciences Institute, located in Koshland Hall, provides access to instrumentation including mass spectrometry, high throughput liquid handling device, various chromatorgraphy applications, and fermentation.
Accepts organic, soil, water, and air samples for analysis of stable isotopes of carbon, nitrogen, sulphur, oxygen and hydrogen at natural abundance.
Promotes the understanding of the structures and dynamics of natural products, potential therapeutics, proteins, and nucleic acids at the atomic level. Instruments include a 900 MHz spectrometer equipped with a cryoprobe, along with several other NMR systems.
Provides routine access for liquid- and solid-state NMR experiments, and is primarily used for determining critical aspects of molecular structure and for studying reaction mechanisms qualitatively, as well as quantitatively. Instruments are available at field strengths 300 MHz to 700 MHz with probes to study a broad-band of nuclei (1H-19F and 31P-103Rh).
Provides comprehensive proteomics services using mass spectrometry, determining the protein contents of samples as simple as gel bands or as complicated as whole cell extracts. The facility provides identification of post-translational modifications and relative quantitation as well as consultation regarding sample preparation and experimental design.
Provides routine acquisition of mass spectra and accurate mass measurements of biological, organic, and inorganic compounds, as well as mass measurements of intact proteins, lipids, oligosaccharides, and non-covalent protein-protein and protein-ligand complexes and supramolecular coordination clusters. The facility also provides advanced proteomics analysis and operates an open access laboratory.
Offers automated gene cloning, protein expression, protein purification, and crystallography. In addition to these services, MacroLab can provide reagents such as competent cells.