Innovative Genomics Institute

The Innovative Genomics Institute is composed of diverse researchers with a powerful combined expertise. After the development of the CRISPR-Cas9 system for rewriting DNA, we saw the potential of applying this technology to solve some of humanity’s greatest problems. Our scientists conduct world-class research, driven by the real possibility to cure human disease, end hunger, and protect the environment.

In addition to our scientific efforts, the IGI is committed to advancing public understanding of genome engineering and providing resources for the broader community.

a man looks at plant growing in brightly lit box

In 10 years, CRISPR transformed medicine. Can it now help us deal with climate change?

Coming from a long line of Iowa farmers, David Savage always thought he would do research to improve crops. That dream died in college, when it became clear that any genetic tweak to a crop would take at least a year to test; for some perennials and trees, it could take five to 10 years. Faced with such slow progress, he chose to study the proteins in photosynthetic bacteria instead. But the advent of CRISPR changed all that.

graphic showing how CRISPR edits out the sickle cell mutation in the genome

FDA approves first test of CRISPR to correct genetic defect causing sickle cell disease

Mobilizing colleagues in the then-new Innovative Genome Institute (IGI) — a joint research collaboration between the University of California, Berkeley, and UC San Francisco — they sought to repair the single mutation that makes red blood cells warp and clog arteries, causing excruciating pain and often death.

More infectious COVID variant detected in Berkeley

A more transmissible variant of the coronavirus, first detected in the United Kingdom, has shown up in two UC Berkeley students, as the state announced at least 133 new cases of the variant statewide. The appearance of the new variant, which appears to be about 50% more infectious than earlier variants, reinforces the need to take very seriously public health precautions to prevent spread: wear a mask when around other people, keep at least six feet apart and wash your hands frequently.

Postdoc Patrick Pausch and doctoral student Basem Al-Sayed in front of a computer discussing a new gene-editing protein

Megaphages harbor mini-Cas proteins ideal for gene editing

The DNA-cutting proteins central to CRISPR-Cas9 and related gene-editing tools originally came from bacteria, but a newfound variety of Cas proteins apparently evolved in viruses that infect bacteria

A photo showing a man holding a clear plastic container with small green plants growing inside, under a bright grow light.

Using CRISPR Genome Editing to Make Cyanide-Free Cassava

IGI researchers are using CRISPR to alter the staple crop cassava, making it safer and easier to eat.