Work in my group will focus on transcriptional regulatory networks and their variation between members of a species. When geneticists study a panel of DNA sequences from genetically distinct individuals, they often find that the genomes are riddled with differences, which can confer changes in mRNA expression level for thousands of genes. These naturally occurring regulatory differences can impact medically and agriculturally important phenotypes; in its own right, the genetics of regulatory variation also serves as a rich model system for the study of complex traits. The goal of my group will be to understand the molecular genetic principles that underlie regulatory variation, using computational and experimental approaches, principally in budding yeast.
Research Expertise and Interest
genetics of regulatory variation