We study microbial nutritional interactions using corrinoids, the vitamin B12 family of molecules, as a model nutrient. We are investigating the biosynthesis of corrinoids, how bacteria obtain corrinoids from their environment, and the role of corrinoid sharing in microbial community dynamics. We use a combination of biochemistry, molecular biology, microbiology, modeling, and bioinformatics approaches to explore the molecular basis of corrinoid selectivity and the mechanisms and evolution of nutritional interactions.
Research Expertise and Interest
molecular biology, genetics, microbial biology, chemical biology, cofactors, nutrient exchange, microbial communities, bacteria