James Olzmann

Title
Associate Professor
Department
Dept of Molecular & Cell Biology
Dept of Nutritional Sciences & Toxicology
Phone
(510) 642-1053
Research Expertise and Interest
lipid droplet, lipotoxicity, ferroptosis, ubiquitin, proteasome, ER protein quality control, metabolism, cancer, drug resistance, metabolic disease
Research Description

Cellular metabolic states must perpetually adapt in the face of fluctuating environmental conditions (eg. altered fatty acid levels) to maintain the health of the cell. Determining how the cell monitors and adapts to changing environments is a fundamental question in biology and is imperative for understanding the aberrant cellular physiology that underlies numerous diseases, such as metabolic diseases and cancer.

Lipid droplets are organelles that function as central lipid metabolism hubs, controlling the storage and mobilization of neutral lipids (eg. fat and sterol esters) in the cell. The Olzmann Lab research group applies systems-level strategies and cell biology approaches to understand the mechanisms that regulate lipid droplets and the functions of lipid droplets in maintaining lipid homeostasis. They are particularly interested in how lipid droplet proteome is established and regulated, how lipid droplet interact and communicate with other organelles, and the potential to manipulate lipotoxic pathways to therapeutically target cancer.

In the News

June 14, 2022

Bakar Fellows program names seven new Spark Award recipients

From artificial ligaments and a novel approach to cancer treatment to “soft” batteries and a way to give voice to silent speech, new innovations from UC Berkeley faculty are getting a big vote of support from the Bakar Fellows program. Seven faculty members have been selected to receive the 2022 Bakar Fellows Spark Award, which is designed to accelerate faculty-led research and produce tangible, positive societal impact through commercialization.

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In the News

June 14, 2022

Bakar Fellows program names seven new Spark Award recipients

From artificial ligaments and a novel approach to cancer treatment to “soft” batteries and a way to give voice to silent speech, new innovations from UC Berkeley faculty are getting a big vote of support from the Bakar Fellows program. Seven faculty members have been selected to receive the 2022 Bakar Fellows Spark Award, which is designed to accelerate faculty-led research and produce tangible, positive societal impact through commercialization.
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