Research Expertise and Interest
lipid droplet, lipotoxicity, ferroptosis, ubiquitin, proteasome, ER protein quality control, metabolism, cancer, drug resistance, metabolic disease
The Olzmann research group employs a combination of systems biology, chemical biology, and cell biology strategies to elucidate the principles that regulate cellular lipid homeostasis. They have made several important advances in our understanding of the regulation and functions of neutral lipid storage organelles called lipid droplets. Dysregulation of lipid droplets and lipid metabolism has been implicated in the pathogenesis of numerous diseases, including prevalent metabolic diseases (e.g. obesity and fatty liver disease) and cancer. In addition, they have also made key discoveries of cellular mechanisms that prevent lipotoxic damage in cancer, such as the accumulation of oxidatively damaged phospholipids during a regulated cell death process called ferroptosis. Current research in the Olzmann lab aims to leverage these findings to develop new therapeutics to treat therapy-resistant forms of cancer.