Helen Bateup

The ability of neurons to dynamically alter their activity in response to changes in the internal or external environment is fundamental to our brain's capacity to learn and adapt. Importantly, this remarkable plasticity must be balanced by mechanisms that ensure stable activity at the level of neural circuits. Understanding the molecular machinery that allows neurons to both be dynamic and maintain balance is a fundamental goal of our research. Perturbations in neural circuit plasticity and homeostasis are associated with several neurological and psychiatric disorders. Therefore, a main focus of our work is to understand how molecular changes associated with these diseases lead to unbalanced neural activity.