My group is interested in understanding molecular mechanisms of membrane proteins that mediate transport of ions and molecules across lipid bilayers. Selective and regulated transport by these channels and transporters underlies many important processes in all living cells, such as import and export of nutrients and electrolytes across cell membranes, secretion of proteins and peptides, and generation of electric signals in neurons and muscle cells. To understand how these molecular machines work, we combine structural, biochemical, and biophysical approaches. Particularly we use cryo-electron microscopy (cryo-EM) to determine atomic structures of protein complexes.
Research Expertise and Interest
protein function, Structural Biology, biochemistry, membrane proteins