Research Expertise and Interest

evolution of sex and recombination, Y degeneration, dosage compensation, sexually antagonistic variation

Research Description

Research in our lab combines both computational and experimental approaches to address a broad range of topics in Evolutionary and Functional Genomics including: (1) Determining the evolutionary benefits of sex and recombination (2) Investigations of large scale changes in patterns of gene expression on evolving sex chromosomes: Dosage compensation of X-linked genes and silencing of Y-linked genes by heterochromatin formation (3) Comparative & functional genomics of young Y chromosomes in Drosophila and mammals (4) Sexual antagonistic variation and feminization & masculinization of evolving X chromosomes (5) Quantifying the mode and strength of selection acting on coding and non-coding DNA in the Drosophila genome (6) Population genetics of Tetrahymena thermophila.