Research Expertise and Interest
nuclear receptor molecular biology, gene regulation
David Moore is a professor in the Department of Nutritional Sciences and Toxicology. His laboratory studies the diverse functions of the nuclear hormone receptors. Dr. Moore’s early studies on nuclear receptor molecular biology and gene regulation have expanded to encompass the roles of nuclear receptors in a variety of mouse models of human disease. We have a particular focus on the roles of diverse nuclear receptors in normal and diseased liver and gut. Their areas of interest include regulation of basic metabolism and its dysregulation in the metabolic syndrome and diabetes, as well as the impact of nuclear receptors in hepatocellular carcinoma, cholestasis, fibrosis and inflammatory bowel diseases.