Researchers use electron microscopy to produce high-resolution images at the atomic scale of everything from composite nanomaterials to single proteins. The technology provides invaluable information on the texture, chemistry, and structure of these materials. Research over the past few decades has focused on achieving higher resolutions: being able to image materials at progressively finer levels with more sensitivity and contrast. But what does the future hold for electron microscopy?

We can directly see the hidden world of atoms thanks to electron microscopes, first developed in the 1930s. Today, electron microscopes, which use beams of electrons to illuminate and magnify a sample, have become even more sophisticated, allowing scientists to take real-world snapshots of materials with a resolution of less than half the diameter of a hydrogen atom. Now, scientists at the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) are pushing the boundaries of electron microscopy even further through a powerful technique called 4D-STEM, a term that stands for “2D raster of 2D diffraction patterns using scanning transmission electron microscopy.”