Srigokul Upadhyayula

Research Expertise and Interest

bioimaging, microscopy, multimodel imaging system, artificial intelligence

Research Description

Srigokul Upadhyayula's research interests bridge applied engineering with basic science. He is interested in mechanistic questions addressed at a molecular level using optical imaging acquired with high temporal and spatial resolution.

His research group is setting up the Advanced BioImaging Center (ABC), a global initiative where we will house cutting-edge pre-commercial imaging technologies, such as the next-generation Adaptive Optical Multi-functional Lattice Light-Sheet Microscope. The ABC will enable imaging across scales spanning several orders of magnitude in space and time in specimens up to several millimeters in extent, or over sessions lasting up to multiple days. These instruments consequently output explosive quantities of immensely complex data and the greatest challenge researchers face is the ability to visualize, analyze and understand the data in order to extract biologically meaningful insights. The prime goal of the ABC is therefore to not only provide cutting-edge microscopy, but also the dedicated human and hardware resources capable of handling tera- to petabyte scale projects and developing robust, open source computational workflows that allow biologists to easily mine the data.  The ABC is interested in leveraging the powerful combination of artificial intelligence tools with the cutting-edge multimodal imaging systems to accelerate the pace of discoveries in both fundamental and translational sciences. 

In the News

New center illuminates ‘microscopic universe within each cell’

In a video posted online this week, Seeker, a San Francisco-based digital media network focused on science and technology, profiled UC Berkeley’s newest cutting-edge facility, the Advanced Bioimaging Center. Run by Srigokul “Gokul” Upadhyayula, a newly arrived assistant professor-in-residence of molecular and cell biology, the center is building imaging systems that will provide real-time video of living cells for biologists who want to understand “how life works,” Upadhyayula told Seeker. He still is awestruck at the “microscopic universe inside each cell,” he said

Featured in the Media

Please note: The views and opinions expressed in these articles are those of the authors and do not necessarily reflect the official policy or positions of UC Berkeley.
November 26, 2019

Your Textbooks are Wrong, This is What Cells Actually Look Like

Seeker
Berkeley's Advanced Bioimaging Center, led by assistant molecular and cell biology professor in residence Srigokul "Gokul" Upadhyayula, is profiled here for its cutting-edge work building imaging systems that will provide real-time video of living cells for biologists. Saying he is still in awe of the "microscopic universe inside each cell," he notes that the new imaging systems, called MOSAIC, employ two techniques -- lattice light-sheet microscopy and adaptive optics -- that were invented by physics professor and Nobel Laureate Eric Betzig. The techniques allow fluorescence imaging of living cells without killing them and remove the blurriness caused by surrounding cells and tissue, respectively. "Biology is probably one of the last human forefronts," Professor Upadhyayula says. "It's the age of exploration, but instead of looking out at the galaxies, we're looking at the galaxies inside the cells." Link to video. For more on this, see a recent faculty feature on Professor Upadhyayula at the Molecular and Cell Biology Department's website.
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