Research Bio

Margaux Pinney is a biochemist whose research harnesses and refines high-throughput enzymology technologies to probe fundamental questions about protein function. Her lab uses microfluidic methods to measure catalytic rates, substrate affinities, and inhibitor sensitivities for thousands of protein variants in parallel, enabling biochemical questions to be addressed at a scale and precision not possible with traditional methods.

The Pinney Lab applies this approach to investigate how proteins evolve new functions, how mutations drive disease and drug resistance, and how enzymes can be engineered for therapeutic applications. By integrating high-dimensional biochemical datasets with machine learning and deep learning, Pinney’s research seeks to reveal general principles of protein biochemistry and accelerate the design of new enzymes and inhibitors with desired properties.

Research Expertise and Interest

chemical biology, high-throughput biochemistry, microfluidics, evolutionary biochemistry, enzyme functional prediction/engineering/design