New Methods for Protein Stoichiometry in Transmembrane Dynamic Signaling Complexes
Nathan Dascal, Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University
Ehud Isacoff, Neurobiology and Molecular and Cell Biology, UC Berkeley
The two participating laboratories are joining forces to accelerate the discovery of quantitative neurotransmitter initiated signaling cascades which are essential for understanding multiple pathologies and for drug development. The array of new methods that will be developed as a result of this collaboration will provide novel tools for the quantitative study of both stable and, importantly, dynamic protein complexes.
Electrically-Actuated Integrated Microfluidic Circuitry
Slava Krylov, Mechanical Engineering, Tel Aviv University
Liwei Lin, Mechanical Engineering, UC Berkeley
Yosi Shacham-Diamand, Physical Electronics, Tel Aviv University
Similar to the way in which integrated circuits revolutionized electronics, the advent of fully autonomous integrated microfluidic circuits could significantly impact diverse chemical, biological, and biomedical applications. This research collaboration will create revolutionary single-layer microfluidic circuit components that include electrically-responsive polymerbased microstructures.
Long Wavelength Photocages for Controlling Neuronal Activity
Evan Miller, Chemistry and Molecular and Cell Biology, UC Berkeley
Roy Weinstain, Molecular Biology and Ecology of Plants, Tel Aviv University
Molecular mechanisms governing biological functions are highly sophisticated and complex. Light is able achieve precise external spatiotemporal control over processes on a molecular level - it is non-invasive and readily delivered with high precision. This collaboration will develop a tunable, general platform for long-wavelength photocaging of bioactive small molecules and apply these cages to neurotransmitters in neurons.
Probing the Interstellar Medium with Massive Spectroscopic Data
Peter Nugent, Astronomy, UC Berkeley and Lawrence Berkeley National Laboratory
Saul Perlmutter, Physics, UC Berkeley
Dovi Poznanski, Physics and Astronomy, Tel Aviv University
David Schlegel, Physics, Lawrence Berkeley National Laboratory
Astronomy is in the midst of a data deluge, with massive surveys generating substantial multi-dimensional datasets that challenge traditional analysis methods. This research collaboration will develop new techniques to find the needles in these astronomical “haystacks”, to provide insight into the bulk constituents of our Galaxy.
Using Caenorhabditis elegans to Study Host-Virus Interactions
Michael Shapira, Professor of Integrative Biology, UC Berkeley
Ella Sklan, Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University
C. elegans is a model organism - an experimental system for studying diverse biological questions, from development to aging, and more recently on host-pathogen interactions - it is a natural host for viral pathogens. Reliable small animal models mimicing major features of viruses such as Dengue and hepatitis C are not available. These researchers will bridge the gap between available tissue culture systems and the lack of reliable small animal models.