Prof. Saybaugh's research is based in numerical methods for neutron transport with an emphasis on supercomputing. Prof. Slaybaugh applies these methods to reactor design, radiation shielding, and nuclear security and nonproliferation. She also teaches software carpentry skills to scientists and engineers, and founded the Nuclear Innovation Bootcamp.
Slaybaugh has served as a Program Director at the Advanced Research Projects Agency - Energy (ARPA-E) where she stood up the fission energy program and managed an agriculture technology portfolio. She is the founding board chair for Good Energy Collective, has served on the Nuclear Energy Advisory Committee (a FACA), and serves on several advisory boards.